Determiner spreading as DP-predication

Determiner Spreading (DS) occurs in adjectivally modified nominal phrases comprising more than one definite article, a phenomenon that has received considerable attention and has been extensively described in Greek. This paper discusses the syntactic properties of DS in detail and argues that DS structures are both arguments and predication configurations involving two DPs. This account successfully captures the word-order facts and the distinctive interpretation of DS, while also laying the groundwork towards unifying it with other structures linking two DPs in a predicative relation

The acquisition of clitic objects in Modern Greek : single clitics, clitic doubling, clitic left dislocation

The present study is concerned with Single Clitics, as weil as with Clitic Doubling and Clitic Left Dislocation constructions and will test the Uniformity Hypothesis (Sportiehe 1992), according to which all three constructions involve the same underlying structure. It will be shown that: - acquisition data pose a problem for the Uniformity Hypothesis (Sportiche 1992) and support rather the idea that Single Clitic, Clitic Doubling and Clitic Left Dislocation constructions do not involve the same underlying structure, - omission of definite articles in Clitic Doubling and Clitic Left Dislocation constructions parallels omission of definite articles in simple DPs, - selective omission of some types of Determiners, i.e. definite articles and use of another type of Determiners, i.e. clitic pronouns, can be explained in terms of the different feature specification of words belonging to the category D and the different status of clitics vs. definite articles

The processing of ambiguous sentences by first and second language learners of English

This study compares the way English-speaking children and adult second language learners of English resolve relative clause attachment ambiguities in sentences such as The dean liked the secretary of the professor who was reading a letter. Two groups of advanced L2 learners of English with Greek or German as their L1 participated in a set of off-line and on-line tasks. While the participants ' disambiguation preferences were influenced by lexical-semantic properties of the preposition linking the two potential antecedent NPs (of vs. with), there was no evidence that they were applying any structure-based ambiguity resolution strategies of the type that have been claimed to influence sentence processing in monolingual adults. These findings differ markedly from those obtained from 6 to 7 yearold monolingual English children in a parallel auditory study (Felser, Marinis, & Clahsen, submitted) in that the children's attachment preferences were not affected by the type of preposition at all. We argue that whereas children primarily rely on structure-based parsing principles during processing, adult L2 learners are guided mainly by non-structural informatio

Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide